Multifaceted role of matrix metalloproteinases (MMPs)
نویسندگان
چکیده
منابع مشابه
Multifaceted role of matrix metalloproteinases (MMPs)
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of α-synuclein patholo...
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Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expressio...
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cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (ca). hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expression of plasm...
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Tumor growth and development involves interaction between tumor cells and extracellular matrix components characterized by cell proliferation, survival, migration into other tissues by invasion or metastasis. Migration of these tumor cells involve degradation of ECM which is facilitated by matrix metalloproteinases (MMPs). Thus MMPs serve useful tool for early diagnosis, prognosis and survival ...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Biosciences
سال: 2015
ISSN: 2296-889X
DOI: 10.3389/fmolb.2015.00019